Christoph Schwarzer Selected Research

Temporal Lobe Epilepsy

1/2022	The Kappa Opioid Receptor System in Temporal Lobe Epilepsy.
10/2019	Dynorphin-based "release on demand" gene therapy for drug-resistant temporal lobe epilepsy.
1/2018	Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis.
1/2017	The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential.
1/2016	The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.
8/2003	Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy.

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Christoph Schwarzer Research Topics

Disease

11	Epilepsy (Aura) 01/2022 - 08/2003
10	Seizures (Absence Seizure) 01/2020 - 01/2003
6	Temporal Lobe Epilepsy 01/2022 - 08/2003
4	AIDS-Related Complex (ARC) 01/2019 - 04/2006
4	Body Weight (Weight, Body) 11/2014 - 05/2002
3	Alzheimer Disease (Alzheimer's Disease) 01/2016 - 07/2013
3	Obesity 06/2014 - 05/2002
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021
1	Blindness (Hysterical Blindness) 01/2021
1	Lissencephaly 01/2021
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2021
1	Intellectual Disability (Idiocy) 01/2021
1	Disease Progression 07/2020
1	Neuroinflammatory Diseases 01/2020
1	Brain Injuries (Brain Injury) 05/2016
1	Gliosis 05/2016
1	Hypoxia (Hypoxemia) 01/2016
1	Multiple Sclerosis 01/2016
1	Myotonic Dystrophy (Dystrophia Myotonica) 01/2016
1	Muscle Weakness 01/2016
1	Pruritus (Itching) 05/2014
1	Psychotic Disorders (Schizoaffective Disorder) 01/2014
1	Substance-Related Disorders (Drug Abuse) 01/2014
1	Autism Spectrum Disorder 01/2014
1	Cognitive Dysfunction 07/2013
1	Osteoporosis 12/2012
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 07/2012
1	Mood Disorders (Mood Disorder) 06/2012
1	Schizophrenia (Dementia Praecox) 09/2009
1	Carcinoma (Carcinomatosis) 08/2009
1	Spinal Dysraphism (Spina Bifida) 01/2009
1	Weight Loss (Weight Reduction) 07/2007
1	Hippocampal Sclerosis 08/2003
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2003
1	Type 2 Diabetes Mellitus (MODY) 12/2002

Drug/Important Bio-Agent (IBA)

12	Dynorphins (Dynorphin)IBA 01/2022 - 04/2007
5	preproenkephalinIBA 01/2014 - 04/2006
4	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2022 - 04/2007
4	gamma-Aminobutyric Acid (GABA)IBA 01/2020 - 01/2003
4	Pentylenetetrazole (Metrazol)IBA 01/2020 - 04/2007
4	Opioid Analgesics (Opioids)IBA 01/2018 - 04/2007
4	Messenger RNA (mRNA)IBA 12/2012 - 06/2002
3	Pharmaceutical PreparationsIBA 01/2021 - 01/2016
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2003
3	Kainic Acid (Kainate)IBA 01/2018 - 01/2003
3	Neuropeptide YIBA 06/2014 - 05/2002
2	Bumetanide (Bumex)FDA LinkGeneric 01/2020 - 01/2020
2	Neurotransmitter Agents (Neurotransmitter)IBA 05/2014 - 04/2006
2	Peptides (Polypeptides)IBA 09/2011 - 04/2007
2	Anticonvulsants (Antiepileptic Drugs)IBA 04/2007 - 01/2004
1	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 01/2021
1	Retinaldehyde (Retinal)IBA 01/2021
1	Caspase 2IBA 01/2021
1	Oxygen (Dioxygen)IBA 07/2020
1	ChloridesIBA 01/2020
1	Minocycline (Cyclops)FDA LinkGeneric 01/2020
1	pre-prodynorphinIBA 10/2019
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2019
1	EnkephalinsIBA 01/2018
1	Opioid Receptors (Opioid Receptor)IBA 01/2017
1	LigandsIBA 01/2017
1	(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamideIBA 01/2016
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2016
1	6'-guanidinonaltrindoleIBA 01/2016
1	CalciumIBA 01/2016
1	LipidsIBA 01/2016
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016
1	GTP-Binding Proteins (G-Protein)IBA 01/2016
1	Cadmium Chloride (Cadmium Dichloride)IBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 06/2014
1	Homer Scaffolding Proteins (Homer 1)IBA 07/2013
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 07/2013
1	Opiate AlkaloidsIBA 12/2012
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 12/2012
1	Potassium Channels (Potassium Channel)IBA 07/2012
1	Hormones (Hormone)IBA 06/2012
1	Neuroprotective AgentsIBA 09/2011
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2009
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2009
1	Fatty Acids (Saturated Fatty Acids)IBA 07/2007
1	NeuropeptidesIBA 04/2007
1	GABA AntagonistsIBA 01/2004
1	GABA-A Receptors (GABA(A) Receptor)IBA 08/2003
1	SodiumIBA 01/2003
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2003
1	vesicular GABA transporterIBA 01/2003
1	4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)IBA 01/2003
1	GABA Plasma Membrane Transport ProteinsIBA 01/2003
1	MelanocortinsIBA 12/2002
1	Cocaine (Cocaine HCl)IBA 06/2002
1	Amphetamine (Amfetamine)FDA LinkGeneric 06/2002
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 06/2002
1	Pancreatic Polypeptide (Pancreatic Polypeptide (PP))IBA 05/2002

Therapy/Procedure

4	Therapeutics 06/2014 - 01/2004
1	Induced Hyperthermia (Thermotherapy) 11/2014